منابع مشابه
A clarification of the Hardy-Weinberg law.
C. C. Li showed that Hardy-Weinberg proportions (HWP) can be maintained in a large population by nonrandom mating as well as random mating. In particular he gave the mating matrix for the symmetric case in the most general form possible. Thus Li showed that, once HWP are attained, the same proportions can be maintained by what he called pseudorandom mating. This article shows that, starting fro...
متن کاملRe-imagining the Hardy-Weinberg Law
Under random mating, a progeny's alleles are independently sampled from the parental gene pools. Here is a new proof which avoids the usual algebraic complexity, based on a restated Mendel's First Law. Another simplified proof along the old approach led to the discovery that allelic independence can hold under random mating and fertility selection. The theoretical existence and number of such s...
متن کاملHardy Weinberg Equilibrium Testing and Interpretation: Focus on infection
Hardy-Weinberg equilibrium (HWE) holds when, in a closed population with random mating and without mutation and natural selection, genotype frequencies at any locus is a simple function of allele frequencies. Testing for HWE is now a common practice in population genetics and genetic association studies of non-communicable diseases; however, it is less-regarded, or sometimes miss-interpreted, i...
متن کاملOn S.N. Bernstein’s derivation of Mendel’s Law and ‘rediscovery’ of the Hardy-Weinberg distribution
Around 1923 the soon-to-be famous Soviet mathematician and probabilist Sergei N. Bernstein started to construct an axiomatic foundation of a theory of heredity. He began from the premise of stationarity (constancy of type proportions) from the first generation of offspring. This led him to derive the Mendelian coefficients of heredity. It appears that he had no direct influence on the subsequen...
متن کاملWhich Exact Test is More Powerful in Testing the Hardy-Weinberg Law?
The asymptotic chi-square test for testing the Hardy–Weinberg law is unreliable in either small or unbalanced samples. As an alternative, either the unconditional or conditional exact test might be used. It is known that the unconditional exact test has greater power than the conditional exact test in small samples. In this article, we show that the conditional exact test is more powerful than ...
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ژورنال
عنوان ژورنال: Genetics and Molecular Biology
سال: 2007
ISSN: 1415-4757
DOI: 10.1590/s1415-47572007000400026